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1. Goldberg RJ, Gore JM, Alpert JS, Dalen JE: Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study. Clin Cardiol; 1987 Jan;10(1):3-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study.
  • As part of an ongoing community-wide study of time trends in the incidence and case-fatality rates of patients hospitalized with acute myocardial infarction (MI) in all 16 Worcester, Massachusetts, metropolitan hospitals during the years 1975, 1978, 1981, and 1984, changes over time in the therapeutic management of 3263 patients with validated acute myocardial infarction were examined.
  • Lidocaine use increased between 1975 (31%) and 1978 (52%) and then leveled off to being used in approximately 45% of hospitalized patients with acute MI in 1981 and 1984.
  • A variety of demographic (e.g., age, sex, teaching hospital) and clinical characteristics (e.g., MI order, MI type, MI location, peak CPK findings, occurrence of acute clinical complications) were also associated with the use of these therapies for the combined study periods.
  • The results of this population-based study suggest considerable changes over time in the therapeutic management of patients hospitalized with acute myocardial infarction and of numerous patient demographic and clinical factors associated with their use.
  • [MeSH-major] Myocardial Infarction / drug therapy

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  • (PMID = 2880685.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Arrhythmia Agents; 0 / Nitrates; 73K4184T59 / Digoxin; 98PI200987 / Lidocaine
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2. Quah JL, Yap S, Cheah SO, Ng YY, Goh ES, Doctor N, Leong BS, Tiah L, Chia MY, Ong ME: Knowledge of signs and symptoms of heart attack and stroke among Singapore residents. Biomed Res Int; 2014;2014:572425
MedlinePlus Health Information. consumer health - Stroke.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Knowledge of signs and symptoms of heart attack and stroke among Singapore residents.
  • AIM: To determine the level of knowledge of signs and symptoms of heart attack and stroke in Singapore resident population, in comparison to the global community.
  • METHODS: A population based, random sample of 7,840 household addresses was selected from a validated national sampling frame.
  • Each participant was asked eight questions on signs and symptoms of heart attack and 10 questions on stroke.
  • The level of knowledge for preselected, common signs and symptoms of heart attack and stroke was 57.8% and 57.1%, respectively.
  • The respondents scored a mean of 5.0 (SD 2.4) out of 8 for heart attack, while they scored a mean of 6.8 (SD 2.9) out of 10 for stroke.
  • The level of knowledge of signs and symptoms of heart attack and stroke in Singapore is comparable to USA and Canada.
  • CONCLUSION: We found a comparable knowledge of stroke and heart attack signs and symptoms in the community to countries within the same economic, educational, and healthcare strata.
  • [MeSH-major] Health Knowledge, Attitudes, Practice. Heart Failure / epidemiology. Stroke / epidemiology
  • [MeSH-minor] Adult. Data Collection. Demography. Female. Humans. Logistic Models. Middle Aged. Risk Factors. Singapore / epidemiology

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  • (PMID = 24812623.001).
  • [ISSN] 2314-6141
  • [Journal-full-title] BioMed research international
  • [ISO-abbreviation] Biomed Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4000924
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3. Jia L, Zhang W, Ma Y, Chen B, Liu Y, Piao C, Wang Y, Yang M, Liu T, Zhang J, Li T, Nie S, Du J: Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction. J Am Heart Assoc; 2017 Jul 19;6(7)
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  • [Title] Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction.
  • METHODS AND RESULTS: Senescence-related genes (ie, p21, p53, and ataxia telangiectasia mutated [ATM]) were shown to be elevated after myocardial infarction (MI) in both mouse and human hearts.
  • Ten- to 12-week-old male wild-type littermates (ATM<sup>+/+</sup>) and ATM heterozygous mice (ATM<sup>+/-</sup>) were subjected to MI.
  • Cardiac echography showed that ATM haplodeficiency did not affect the survival rate but aggravated heart failure at day 28 post MI.
  • Costaining of α-smooth muscle actin with p53 or p19 showed fewer senescent myofibroblasts in ATM<sup>+/-</sup> mouse hearts.
  • Moreover, angiogenesis was also examined using the endothelial markers CD31 both at early (day 7) and late stages (day 28) after MI, and ATM haplodeficiency reduced angiogenesis after MI.
  • Finally, cardiac fibroblasts were isolated from infarcted mouse heart and the medium were tested for its capacity of endothelial tubing formation, revealing that ATM haplodeficiency led to lower vascular endothelial growth factor production from cardiac fibroblast and reduced capacity of endothelial tube formation in vitro.
  • CONCLUSIONS: The present study shows that ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor production and impaired angiogenesis in response to MI, leading to accelerated heart failure.

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  • [Copyright] © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
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  • (PMID = 28724653.001).
  • [ISSN] 2047-9980
  • [Journal-full-title] Journal of the American Heart Association
  • [ISO-abbreviation] J Am Heart Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; angiogenesis / fibroblasts / myocardial infarction / senescence / vascular endothelial growth factor
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4. Oser CS, Gohdes D, Fogle CC, Tadios F, Doore V, Bell DS, Harwell TS, Helgerson SD: Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010. Prev Chronic Dis; 2013 May 16;10:E80
MedlinePlus Health Information. consumer health - Stroke.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010.
  • INTRODUCTION: National initiatives to improve the recognition of heart attack and stroke warning signs have encouraged symptomatic people to seek early treatment, but few have shown significant effects in rural American Indian (AI) communities.
  • METHODS: During 2009 and 2010, the Montana Cardiovascular Health Program, in collaboration with 2 tribal health departments, developed and conducted culturally specific public awareness campaigns for signs and symptoms of heart attack and stroke via local media.
  • RESULTS: Knowledge of 3 or more heart attack warning signs and symptoms increased significantly on 1 reservation from 35% at baseline to 47% postcampaign.
  • On the second reservation, recognition of 2 or more stroke signs and symptoms increased from 62% at baseline to 75% postcampaign, and the level of awareness remained at 73% approximately 4 months after the high-intensity campaign advertisements ended.
  • Intent to call 9-1-1 did not increase in the heart attack campaign but did improve in the stroke campaign for specific symptoms.
  • Recall of media campaigns on both reservations increased significantly from baseline to postcampaign for both media outlets (ie, radio and newspaper).
  • CONCLUSION: Carefully designed, culturally specific campaigns may help eliminate disparities in the recognition of heart attack and stroke warning signs in AI communities.

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  • (PMID = 23680509.001).
  • [ISSN] 1545-1151
  • [Journal-full-title] Preventing chronic disease
  • [ISO-abbreviation] Prev Chronic Dis
  • [Language] ENG
  • [Grant] United States / NCCDPHP CDC HHS / DP / U50 DP000736; United States / NCCDPHP CDC HHS / DP / 5U50DP000736-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3666974
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5. Ratkov I, Sipetić S, Vlajinac H, Sekeres B: [Mortality from heart attack in Belgrade population during the period 1990-2004]. Srp Arh Celok Lek; 2008 Nov-Dec;136(11-12):598-602
MedlinePlus Health Information. consumer health - Heart Attack.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mortality from heart attack in Belgrade population during the period 1990-2004].
  • INTRODUCTION: In most countries, cardiovascular diseases are the leading disorders, with ischemic heart diseases being the leading cause of death.
  • According to WHO data, every year about 17 million people die of cardiovascular diseases, which is 30% of all deaths.
  • Ischemic heart diseases contribute from one-third to one-half of all deaths due to cardiovascular diseases.
  • Three point eight million men and 3.4 million women in the world die every year from ischemic heart diseases, and in Europe about 2 million.
  • The highest mortality rate from ischemic heart diseases occurs in India, China and Russia.
  • OBJECTIVE: The aim of this descriptive epidemiological study was to determine heart attack mortality in Belgrade population during the period 1990-2004.
  • METHOD: In the study, we conducted investigation of Belgrade population during the period 1990-2004.
  • The mortality rates were standardized using the direct method of standardization according to the world (Segi) standard population.
  • RESULTS: In the Belgrade population during the period 1990-2004, the participation of mortality rate due to heart attack among deaths from cardiovascular diseases was 17% in males and 10% in females.
  • In Belgrade male population, mean standardized mortality rates (per 100,000 habitants) were 50.5 for heart attack, 8.3 for chronic ischemic heart diseases and 4.6 for angina pectoris, while in females the rates were 30.8, 6.7 and 4.2, respectively.
  • Mortality from ischemic heart diseases and from heart attack was higher in males than in females.
  • During the studied 15-year period, on average 755 males and 483 females died due to heart attack every year.
  • Males died 1.6 times more frequently from heart attack than females.
  • During the studied period, mean standardized mortality rates from heart attack, in the population aged over 30 increased with age both in male and female population.
  • However, males tended to die from heart attack at an earlier age than females, with death rates for males approximately the same as those for women who were 10 years older.
  • CONCLUSION: In Belgrade during the period from 1990-2004, we found that there was an increasing trend in mortality rate due to cardiovascular diseases, while the trend of mortality rate from heart attack was constant with insignificant oscillations.
  • [MeSH-major] Myocardial Infarction / mortality

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  • (PMID = 19177820.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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6. Korpi RM, Alestalo K, Ruuska T, Lammentausta E, Borra R, Yannopoulos F, Lehtonen S, Korpi JT, Lappi-Blanco E, Anttila V, Lehenkari P, Juvonen T, Blanco Sequieros R: Two novel direct SPIO labels and in vivo MRI detection of labeled cells after acute myocardial infarct. Acta Radiol Open; 2017 Aug;6(8):2058460117718407

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two novel direct SPIO labels and in vivo MRI detection of labeled cells after acute myocardial infarct.
  • BACKGROUND: Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide.
  • Cellular decay due hypoxia requires rapid and validated methods for possible therapeutic cell transplantation.
  • PURPOSE: To develop direct and rapid superparamagnetic iron oxide (SPIO) cell label for a large-animal model and to assess in vivo cell targeting by magnetic resonance imaging (MRI) in an experimental AMI model.
  • MATERIAL AND METHODS: Bone marrow mononuclear cells (BMMNCs) were labeled with SPIO particles using two novel direct labeling methods (rotating incubation method and electroporation).
  • An AMI porcine model was used to evaluate the direct labeling method (rotating incubation method) by examining targeting of labeled BMMNCs using MRI and histology.
  • The extent of macroscopic pathological myocardial changes (hemorrhage) correlated with altered function detected on MRI.
  • CONCLUSION: We demonstrated two novel direct SPIO labeling methods and demonstrated the feasibility of clinical MRI for monitoring targeting of the labeled cells in animal models of AMI.

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  • (PMID = 28811932.001).
  • [ISSN] 2058-4601
  • [Journal-full-title] Acta radiologica open
  • [ISO-abbreviation] Acta Radiol Open
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Magnetic resonance imaging (MRI) / acute myocardial infarct (AMI) / bone marrow mononuclear cells (BMMNCs) / superparamagnetic iron oxide (SPIO) particles / transplantation
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7. Thompson PL, Shilton T: Encouraging early treatment of suspected heart attack: it's OK to call 000. Med J Aust; 2017 Jan 16;206(1):19

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Encouraging early treatment of suspected heart attack: it's OK to call 000.

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  • (PMID = 28076730.001).
  • [ISSN] 1326-5377
  • [Journal-full-title] The Medical journal of Australia
  • [ISO-abbreviation] Med. J. Aust.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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8. Bahr RD: The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000. J Cardiovasc Manag; 1995 May-Jun;6(3):19-23
MedlinePlus Health Information. consumer health - Heart Attack.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000.
  • Within the last four years, more than 500 chest pain centers have developed in response to new paradigms for early heart attack care.
  • These shifting paradigms now focus on acute prevention, in terms of both early thrombolytic therapy and cardioprotection of patients with prodromal symptoms of a heart attack.
  • [MeSH-major] Cardiology Service, Hospital. Health Promotion / trends. Myocardial Infarction / therapy
  • [MeSH-minor] Cardiopulmonary Resuscitation. Chest Pain / diagnosis. Health Education. Humans. Pain Clinics. Thrombolytic Therapy / trends. United States

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  • (PMID = 10143350.001).
  • [ISSN] 1053-5330
  • [Journal-full-title] The Journal of cardiovascular management : the official journal of the American College of Cardiovascular Administrators
  • [ISO-abbreviation] J Cardiovasc Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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9. Tsai J, Shen J: Exploring the Link Between Posttraumatic Stress Disorder and inflammation-Related Medical Conditions: An Epidemiological Examination. Psychiatr Q; 2017 Mar 25;

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exploring the Link Between Posttraumatic Stress Disorder and inflammation-Related Medical Conditions: An Epidemiological Examination.
  • This study examined the relation between posttraumatic stress disorder (PTSD) and inflammation-related medical conditions using data from the 2013-2014 New York City Health and Nutrition Examination Survey.
  • PTSD was strongly associated with increased odds for hypercholesterolemia, insulin resistance, angina, heart attack, and emphysema with the greatest odds observed for heart attack (OR= 3.94) and emphysema (OR= 4.06).
  • But PTSD was also associated with lower odds for hypertension, type 1 diabetes, asthma, coronary heart disease, stroke, osteoporosis, and a failing kidney with the lowest odds observed for type 1 diabetes (OR= 0.43).

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  • (PMID = 28342139.001).
  • [ISSN] 1573-6709
  • [Journal-full-title] The Psychiatric quarterly
  • [ISO-abbreviation] Psychiatr Q
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Cardiovascular diseases / Inflammation / Posttraumatic stress disorder / Pulmonary diseases
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10. Silvet H, Spencer F, Yarzebski J, Lessard D, Gore JM, Goldberg RJ: Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study. Arch Intern Med; 2003 Oct 13;163(18):2175-83
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study.
  • BACKGROUND: Despite the benefits associated with beta-blocker therapy in patients with acute myocardial infarction (AMI), limited recent data are available describing the extent of use of this therapy and the associated hospital and long-term outcomes, particularly from the perspective of a population-based study.
  • Data are also limited about the characteristics of patients with AMI who do not receive beta-blockers.
  • This study examines more than 2 decades of trends in the use of beta-blockers in hospitalized patients with AMI.
  • METHODS: Communitywide study of 10,374 patients hospitalized with confirmed AMI in all metropolitan Worcester hospitals during 12 annual periods between 1975 and 1999.
  • After controlling for other prognostic factors, patients treated with beta-blockers were less likely to develop heart failure (adjusted odds ratio [OR], 0.58; 95% confidence interval [CI], 0.53-0.63), cardiogenic shock (OR, 0.46; 95% CI, 0.39-0.54), and primary ventricular fibrillation (OR, 0.84; 95% CI, 0.65-1.08) and were less likely to die (OR, 0.26; 95% CI, 0.22-0.29) during hospitalization than were patients who did not receive this therapy.
  • CONCLUSIONS: The results of this observational study demonstrate encouraging trends in the use of beta-blockers in hospitalized patients with AMI and document the benefits to be gained from this treatment.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Myocardial Infarction / drug therapy. Practice Patterns, Physicians' / trends

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  • (PMID = 14557215.001).
  • [ISSN] 0003-9926
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL35434
  • [Publication-type] Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists
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