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1. Goldberg RJ, Gore JM, Alpert JS, Dalen JE: Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study. Clin Cardiol; 1987 Jan;10(1):3-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study.
  • As part of an ongoing community-wide study of time trends in the incidence and case-fatality rates of patients hospitalized with acute myocardial infarction (MI) in all 16 Worcester, Massachusetts, metropolitan hospitals during the years 1975, 1978, 1981, and 1984, changes over time in the therapeutic management of 3263 patients with validated acute myocardial infarction were examined.
  • Lidocaine use increased between 1975 (31%) and 1978 (52%) and then leveled off to being used in approximately 45% of hospitalized patients with acute MI in 1981 and 1984.
  • A variety of demographic (e.g., age, sex, teaching hospital) and clinical characteristics (e.g., MI order, MI type, MI location, peak CPK findings, occurrence of acute clinical complications) were also associated with the use of these therapies for the combined study periods.
  • The results of this population-based study suggest considerable changes over time in the therapeutic management of patients hospitalized with acute myocardial infarction and of numerous patient demographic and clinical factors associated with their use.
  • [MeSH-major] Myocardial Infarction / drug therapy

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  • (PMID = 2880685.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Arrhythmia Agents; 0 / Nitrates; 73K4184T59 / Digoxin; 98PI200987 / Lidocaine
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2. Quah JL, Yap S, Cheah SO, Ng YY, Goh ES, Doctor N, Leong BS, Tiah L, Chia MY, Ong ME: Knowledge of signs and symptoms of heart attack and stroke among Singapore residents. Biomed Res Int; 2014;2014:572425
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Knowledge of signs and symptoms of heart attack and stroke among Singapore residents.
  • AIM: To determine the level of knowledge of signs and symptoms of heart attack and stroke in Singapore resident population, in comparison to the global community.
  • METHODS: A population based, random sample of 7,840 household addresses was selected from a validated national sampling frame.
  • Each participant was asked eight questions on signs and symptoms of heart attack and 10 questions on stroke.
  • The level of knowledge for preselected, common signs and symptoms of heart attack and stroke was 57.8% and 57.1%, respectively.
  • The respondents scored a mean of 5.0 (SD 2.4) out of 8 for heart attack, while they scored a mean of 6.8 (SD 2.9) out of 10 for stroke.
  • The level of knowledge of signs and symptoms of heart attack and stroke in Singapore is comparable to USA and Canada.
  • CONCLUSION: We found a comparable knowledge of stroke and heart attack signs and symptoms in the community to countries within the same economic, educational, and healthcare strata.
  • [MeSH-major] Health Knowledge, Attitudes, Practice. Heart Failure / epidemiology. Stroke / epidemiology
  • [MeSH-minor] Adult. Data Collection. Demography. Female. Humans. Logistic Models. Middle Aged. Risk Factors. Singapore / epidemiology

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  • (PMID = 24812623.001).
  • [ISSN] 2314-6141
  • [Journal-full-title] BioMed research international
  • [ISO-abbreviation] Biomed Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Rorabaugh BR, Seeley SL, Stoops TS, D'Souza MS: Repeated exposure to methamphetamine induces sex-dependent hypersensitivity to ischemic injury in the adult rat heart. PLoS One; 2017;12(6):e0179129
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  • [Title] Repeated exposure to methamphetamine induces sex-dependent hypersensitivity to ischemic injury in the adult rat heart.
  • BACKGROUND: We previously reported that adult female, but not male rats that were prenatally exposed to methamphetamine exhibit myocardial hypersensitivity to ischemic injury.
  • The goal of this study was to determine whether methamphetamine exposure during adulthood sensitizes the heart to ischemic injury.
  • METHODS: Adult male and female rats received daily injections of methamphetamine (5 mg/kg) or saline for 10 days.
  • Their hearts were isolated on day 11 and subjected to a 20 min ischemic insult on a Langendorff isolated heart apparatus.
  • Cardiac contractile function was measured by an intraventricular balloon, and infarct size was measured by triphenyltetrazolium chloride staining.
  • RESULTS: Hearts from methamphetamine-treated females exhibited significantly larger infarcts and suppressed postischemic recovery of contractile function compared to hearts from saline-treated females.
  • In contrast, methamphetamine had no effect on infarct size or contractile recovery in male hearts.
  • Subsequent experiments demonstrated that hypersensitivity to ischemic injury persisted in female hearts following a 1 month period of abstinence from methamphetamine.
  • Myocardial protein kinase C-ε expression, Akt phosphorylation, and ERK phosphorylation were unaffected by adult exposure to methamphetamine.
  • CONCLUSIONS: Exposure of adult rats to methamphetamine sex-dependently increases the extent of myocardial injury following an ischemic insult.
  • These data suggest that women who have a heart attack might be at risk of more extensive myocardial injury if they have a recent history of methamphetamine abuse.
  • [MeSH-major] Central Nervous System Stimulants / adverse effects. Heart / drug effects. Heart / physiopathology. Methamphetamine / adverse effects. Myocardial Infarction / etiology. Myocardial Ischemia / complications
  • [MeSH-minor] Animals. Female. Male. Myocardial Contraction / drug effects. Myocardium / pathology. Rats. Rats, Sprague-Dawley. Sex Factors

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  • (PMID = 28575091.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 44RAL3456C / Methamphetamine
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4. Thomas MM, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH: Mental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study. Prim Care Companion CNS Disord; 2017 Jun 22;19(3)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Methods: Data were analyzed from the National Health and Resilience in Veterans Study (NHRVS), a contemporary, nationally representative survey of 1,480 US veterans conducted September-October 2013.
  • After adjustment for these sociodemographic and military differences, combat veterans were more than 3 times as likely as noncombat veterans to screen positive for lifetime posttraumatic stress disorder (PTSD) and more than twice as likely for current PTSD and had 82% greater odds of screening positive for current generalized anxiety disorder.
  • After additionally controlling for lifetime diagnoses of PTSD and depression, alcohol or drug use disorder, and nicotine dependence, combat veterans had 68% greater odds of having attempted suicide and 85% and 38% greater odds of being diagnosed with a stroke and chronic pain, respectively.
  • Younger combat veterans were more likely than older combat veterans to screen positive for lifetime (30.6% vs 10.1%) and current PTSD (19.2% vs 4.9%) and suicidal ideation (18.6% vs 6.9%) and to have been diagnosed with migraine headaches (12.8% vs 2.1%), while older combat veterans were more likely than younger combat veterans to report having been diagnosed with heart disease (19.2% vs 2.6%) and heart attack (13.9% vs 2.5%).
  • Conclusions: Compared to noncombat veterans in the United States, combat veterans have elevated rates of PTSD, suicide attempt, stroke, and chronic pain independent of other sociodemographic, military, and mental health factors.
  • Younger combat veterans have elevated rates of PTSD, suicidal ideation, and migraine headaches, while older combat veterans have elevated rates of heart disease and heart attack.

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  • (PMID = 28657698.001).
  • [ISSN] 2155-7780
  • [Journal-full-title] The primary care companion for CNS disorders
  • [ISO-abbreviation] Prim Care Companion CNS Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Bahr RD: The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000. J Cardiovasc Manag; 1995 May-Jun;6(3):19-23
MedlinePlus Health Information. consumer health - Heart Attack.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000.
  • Within the last four years, more than 500 chest pain centers have developed in response to new paradigms for early heart attack care.
  • These shifting paradigms now focus on acute prevention, in terms of both early thrombolytic therapy and cardioprotection of patients with prodromal symptoms of a heart attack.
  • [MeSH-major] Cardiology Service, Hospital. Health Promotion / trends. Myocardial Infarction / therapy
  • [MeSH-minor] Cardiopulmonary Resuscitation. Chest Pain / diagnosis. Health Education. Humans. Pain Clinics. Thrombolytic Therapy / trends. United States

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  • (PMID = 10143350.001).
  • [ISSN] 1053-5330
  • [Journal-full-title] The Journal of cardiovascular management : the official journal of the American College of Cardiovascular Administrators
  • [ISO-abbreviation] J Cardiovasc Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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6. Ratkov I, Sipetić S, Vlajinac H, Sekeres B: [Mortality from heart attack in Belgrade population during the period 1990-2004]. Srp Arh Celok Lek; 2008 Nov-Dec;136(11-12):598-602
MedlinePlus Health Information. consumer health - Heart Attack.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mortality from heart attack in Belgrade population during the period 1990-2004].
  • INTRODUCTION: In most countries, cardiovascular diseases are the leading disorders, with ischemic heart diseases being the leading cause of death.
  • According to WHO data, every year about 17 million people die of cardiovascular diseases, which is 30% of all deaths.
  • Ischemic heart diseases contribute from one-third to one-half of all deaths due to cardiovascular diseases.
  • Three point eight million men and 3.4 million women in the world die every year from ischemic heart diseases, and in Europe about 2 million.
  • The highest mortality rate from ischemic heart diseases occurs in India, China and Russia.
  • OBJECTIVE: The aim of this descriptive epidemiological study was to determine heart attack mortality in Belgrade population during the period 1990-2004.
  • METHOD: In the study, we conducted investigation of Belgrade population during the period 1990-2004.
  • The mortality rates were standardized using the direct method of standardization according to the world (Segi) standard population.
  • RESULTS: In the Belgrade population during the period 1990-2004, the participation of mortality rate due to heart attack among deaths from cardiovascular diseases was 17% in males and 10% in females.
  • In Belgrade male population, mean standardized mortality rates (per 100,000 habitants) were 50.5 for heart attack, 8.3 for chronic ischemic heart diseases and 4.6 for angina pectoris, while in females the rates were 30.8, 6.7 and 4.2, respectively.
  • Mortality from ischemic heart diseases and from heart attack was higher in males than in females.
  • During the studied 15-year period, on average 755 males and 483 females died due to heart attack every year.
  • Males died 1.6 times more frequently from heart attack than females.
  • During the studied period, mean standardized mortality rates from heart attack, in the population aged over 30 increased with age both in male and female population.
  • However, males tended to die from heart attack at an earlier age than females, with death rates for males approximately the same as those for women who were 10 years older.
  • CONCLUSION: In Belgrade during the period from 1990-2004, we found that there was an increasing trend in mortality rate due to cardiovascular diseases, while the trend of mortality rate from heart attack was constant with insignificant oscillations.
  • [MeSH-major] Myocardial Infarction / mortality

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  • (PMID = 19177820.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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7. Esmaeili R, Sadeghpour A, Darbandi-Azar A, Majidzadeh-A K, Vajhi A, Sadeghizadeh M: Echocardiographic assessment of myocardial infarction: comparison of a rat model in two strains. Iran J Vet Res; 2017;18(1):30-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Echocardiographic assessment of myocardial infarction: comparison of a rat model in two strains.
  • The purpose of this study was to induce myocardial infarction (MI) and compare the echocardiographic parameters and mortality ratio of Lewis inbred and Wistar outbred strain before and after the procedure to help choose the best one for MI studies.
  • In this study MI was induced in 46 Lewis and 34 Wistar by occlusion of left anterior descending artery (LAD).
  • Interventricular septum diastolic and systolic dimension (IVSd, s), diastolic and systolic left ventricular internal diameter (LVIDd, s), diastolic and systolic left ventricular posterior wall dimension (LVPWd, s), ejection fraction (EF), and fractional shortening (FS).
  • The significant changes were observed in systolic IVS, LVID and EF and FS before and after MI and no significant difference was detected between Lewis and Wistar.
  • As a conclusion the echocardiographic parameters of these two strains were similar, but according to mortality rate and more cardiac anatomic variation in Lewis rats, Wistar is better for MI studies.

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  • (PMID = 28588630.001).
  • [ISSN] 1728-1997
  • [Journal-full-title] Iranian journal of veterinary research
  • [ISO-abbreviation] Iran J Vet Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Keywords] NOTNLM ; Echocardiography / Lewis / Mortality ratio / Myocardial infarction / Rat model
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8. Oser CS, Gohdes D, Fogle CC, Tadios F, Doore V, Bell DS, Harwell TS, Helgerson SD: Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010. Prev Chronic Dis; 2013 May 16;10:E80
MedlinePlus Health Information. consumer health - Stroke.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010.
  • INTRODUCTION: National initiatives to improve the recognition of heart attack and stroke warning signs have encouraged symptomatic people to seek early treatment, but few have shown significant effects in rural American Indian (AI) communities.
  • METHODS: During 2009 and 2010, the Montana Cardiovascular Health Program, in collaboration with 2 tribal health departments, developed and conducted culturally specific public awareness campaigns for signs and symptoms of heart attack and stroke via local media.
  • RESULTS: Knowledge of 3 or more heart attack warning signs and symptoms increased significantly on 1 reservation from 35% at baseline to 47% postcampaign.
  • On the second reservation, recognition of 2 or more stroke signs and symptoms increased from 62% at baseline to 75% postcampaign, and the level of awareness remained at 73% approximately 4 months after the high-intensity campaign advertisements ended.
  • Intent to call 9-1-1 did not increase in the heart attack campaign but did improve in the stroke campaign for specific symptoms.
  • Recall of media campaigns on both reservations increased significantly from baseline to postcampaign for both media outlets (ie, radio and newspaper).
  • CONCLUSION: Carefully designed, culturally specific campaigns may help eliminate disparities in the recognition of heart attack and stroke warning signs in AI communities.

  • MedlinePlus Health Information. consumer health - Native American Health.
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  • (PMID = 23680509.001).
  • [ISSN] 1545-1151
  • [Journal-full-title] Preventing chronic disease
  • [ISO-abbreviation] Prev Chronic Dis
  • [Language] ENG
  • [Grant] United States / NCCDPHP CDC HHS / DP / U50 DP000736; United States / NCCDPHP CDC HHS / DP / 5U50DP000736-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3666974
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9. Silvet H, Spencer F, Yarzebski J, Lessard D, Gore JM, Goldberg RJ: Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study. Arch Intern Med; 2003 Oct 13;163(18):2175-83
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study.
  • BACKGROUND: Despite the benefits associated with beta-blocker therapy in patients with acute myocardial infarction (AMI), limited recent data are available describing the extent of use of this therapy and the associated hospital and long-term outcomes, particularly from the perspective of a population-based study.
  • Data are also limited about the characteristics of patients with AMI who do not receive beta-blockers.
  • This study examines more than 2 decades of trends in the use of beta-blockers in hospitalized patients with AMI.
  • METHODS: Communitywide study of 10,374 patients hospitalized with confirmed AMI in all metropolitan Worcester hospitals during 12 annual periods between 1975 and 1999.
  • After controlling for other prognostic factors, patients treated with beta-blockers were less likely to develop heart failure (adjusted odds ratio [OR], 0.58; 95% confidence interval [CI], 0.53-0.63), cardiogenic shock (OR, 0.46; 95% CI, 0.39-0.54), and primary ventricular fibrillation (OR, 0.84; 95% CI, 0.65-1.08) and were less likely to die (OR, 0.26; 95% CI, 0.22-0.29) during hospitalization than were patients who did not receive this therapy.
  • CONCLUSIONS: The results of this observational study demonstrate encouraging trends in the use of beta-blockers in hospitalized patients with AMI and document the benefits to be gained from this treatment.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Myocardial Infarction / drug therapy. Practice Patterns, Physicians' / trends

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  • (PMID = 14557215.001).
  • [ISSN] 0003-9926
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL35434
  • [Publication-type] Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists
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10. Goldberg RJ, Gore JM, Alpert JS, Dalen JE: Incidence and case fatality rates of acute myocardial infarction (1975-1984): the Worcester Heart Attack Study. Am Heart J; 1988 Apr;115(4):761-7
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence and case fatality rates of acute myocardial infarction (1975-1984): the Worcester Heart Attack Study.
  • During the calendar years 1975, 1978, 1981, and 1984, a community-wide study in the Worcester, Massachusetts, metropolitan area has examined time trends in the attack and case fatality rates of acute myocardial infarction (MI) as well as the occurrence of out-of-hospital coronary heart disease deaths.
  • Between 1975 and 1981, there was a slight increase in the age-adjusted attack rates of acute MI; between 1981 and 1984, however, there was a dramatic decline in the incidence rates of acute MI.
  • These temporal trends over the 10-year period examined resulted in an overall decrease in both the incidence rates of initial (255 per 100,000-1975; 186 per 100,000-1984) as well as recurrent (133 per 100,000-1975; 104 per 100,000-1984) acute MI in the 16 hospitals surveyed.
  • The age-adjusted in-hospital case fatality rates of acute MI declined consistently over the periods studied, from 22.2% in 1975 to 20.3% in 1978, 17.8% in 1981, and to 15.1% in 1984, for an overall decline of 32% over the 10-year period studied.
  • No significant differences, however, were seen in the long-term survival rates of patients discharged from the hospital after acute MI in either 1975, 1978, 1981, or 1984.
  • A consistent decline was seen in the age-adjusted mortality rates (per 100,000) of out-of-hospital coronary heart disease between 1975 (265), 1978 (174), 1981 (170), and 1984 (148).(ABSTRACT TRUNCATED AT 250 WORDS)
  • [MeSH-major] Myocardial Infarction / epidemiology
  • [MeSH-minor] Adult. Coronary Disease / mortality. Female. Hospitalization. Humans. Male. Massachusetts. Middle Aged

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  • (PMID = 3354404.001).
  • [ISSN] 0002-8703
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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